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Nrf2 pathway in detail. The Nrf2 pathway is essentially a network of genes and proteins that govern the body’s antioxidant response. When the body is exposed to oxidative stress or toxins, the Nrf2 pathway is activated, leading to the expression of various genes that help to neutralize these harmful agents. At the cellular level, the Nrf2 pathway works by binding to specific DNA sequences called antioxidant response elements (AREs). When activated, Nrf2 binds to AREs and initiates the transcript
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