The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing …

p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often …

Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology. TP53 is the most frequently mutated gene in …

Dec 19, 2025 · The TP53 gene helps prevent cancer by repairing DNA or causing cell death when DNA is too damaged. Mutations in the TP53 gene are found in over 50% of cancer cases and can lead to …

Jan 15, 2026 · p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (e.g. hypoxia, DNA and spindle damage).

Oct 23, 2024 · It appears that the TP53 gene has emerged as a victim of its own evolutionary past that shaped its structure and function towards a pluripotent tumor suppressor, but came with an increased...

Understanding TP53 And Mutant p53 TP53 mutation is a key distinguishing feature of tumor cells, but the mechanisms by which potential pro-oncologic “gain-of-function” mutations impact cancer …

The TP53 Database compiles various types of data and information from the literature and generalist databases on human TP53 gene variations related to cancer. The database is hosted by the National …

This Special Issue, “Role of TP53 Mutation in Cancer,” aims to provide a comprehensive platform for basic, translational, and clinical studies that deepen our understanding of mutant p53 biology and its …

Sep 7, 2025 · People who are born with changes—called mutations—in the TP53 gene have a syndrome known as Li-Fraumeni syndrome and an increased risk for many different types of cancer.