gut.bmj16h
A reproducible grading scale for histological assessment of inflammation in ulcerative colitis
Dr K Geboes, Department of Pathology, University Hospital, KULeuven, Minderbroedersstraat 12, 3000 Leuven, Belgium. Email: Karel.Geboes{at}uz.kuleuven.ac.be BACKGROUND Evaluation of histological ...
gut.bmj1d
O43 The phenotype and TCR repertoire of intestinal CD8+ T cells is altered in coeliac disease
Introduction Coeliac disease (CD) is a common immune-mediated condition driven by aberrant adaptive CD4+ T cell responses to gluten. The cytotoxic CD8+ and γδ+ T cell response in the epithelium is ...
gut.bmj1d
IDDF2024-ABS-0145 Microscale gut-on-a-chip system for disease modeling
Background With the development of micromanufacturing and 3D printing technologies, gut-on-a-chip provides a new method for studying intestinal diseases in vitro. Based on intestinal functions, gut-on ...
gut.bmj2d
Glutamine deprivation facilitates tumour necrosis factor induced bacterial translocation in Caco-2 cells by depletion of enterocyte fuel substrate
1 Gut Barrier Research Group, and Department of Surgery, University of Manchester, Hope Hospital, Manchester, UK 2 Department of Microbiology, University of Manchester, Hope Hospital, Manchester, UK 3 ...
gut.bmj3d
Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis
Correspondence to Dr Thomas Berg, Section of Hepatology, Department of Internal Medicine, University Hospital Leipzig, Leipzig 04103, Germany; thomas.berg{at}medizin.uni-leipzig.de Objective ...
gut.bmj4d
Guidelines for management of patients with a short bowel
These guidelines aim to help clinicians manage patients who have had an intestinal resection that leaves a short length (about 2 m or less) of small bowel remaining. The preliminary guidelines were ...
gut.bmj4d
Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?
Pancreatic ductal adenocarcinoma (PDAC) constitutes one of the most aggressive malignancies with a 5-year survival rate of <7%. Due to growing incidence, late diagnosis and insufficient treatment ...
gut.bmj5d
Guidelines for screening and surveillance of asymptomatic colorectal cancer in patients with inflammatory bowel disease
Patients with ulcerative colitis (UC) are at increased risk of colorectal carcinoma. 1, 2 Many clinicians practice colonoscopic surveillance in these patients in the hope of detecting dysplasia or an ...
gut.bmj5d
Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-γδ expression
Dr M-L Hammarström, Department of Immunology, Umeå University, S-901 85 Umeå, Sweden. Email:Marie-Louise.Hammarstrom{at}climi.umu.se. BACKGROUND AND AIMS A histopathological feature considered ...
gut.bmj5d
Host–microbiome determinants of insulin resistance in obesity: alone we go faster, together we go further!
It is now widely recognised that host–microbiome interactions play a major role in the control of energy metabolism and ...
gut.bmj6d
BMP-9 interferes with liver regeneration and promotes liver fibrosis
4 Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, Germany 5 German Red Cross Blood Service Baden-Württemberg-Hessen and Institute for Transfusion ...
gut.bmj6d
New therapies for inflammatory bowel disease: from the bench to the bedside
The mechanisms underlying the chronic intestinal inflammation that is a hallmark of inflammatory bowel diseases (IBD) are complex. Components of the pathological response include the adaptive and ...