Life Biosciences tests ER-100, a gene therapy that aims to restore vision by rejuvenating damaged retinal neurons.

Tuberculous Meningitis (TBM) is the most severe form of extrapulmonary tuberculosis, posing a critical global health challenge. This devastating central ...

Neuroscience drug discovery is challenged by the brain’s structural and cell-type complexity, which is difficult to model in cellular systems compatible with high-throughput screening methods. Calcium ...

Researchers from Wuhan Institute of Biomedical Sciences, Jianghan University and collaborators recently showed that activating the endogenous transcription factors Ngn2 and Isl1 via CRISPRa can ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

This is read by an automated voice. Please report any issues or inconsistencies here. Scientists are trying a revolutionary new approach to treat rheumatoid arthritis, multiple sclerosis, lupus and ...

A project led by Johns Hopkins University has successfully imaged astrocytes, the brain's most abundant cells, in their natural state. The star-shaped astrocytes are known to be responsible for ...

Scientists have engineered a nanowire platform that mimics brain tissue to study astrocytes, the star-shaped cells critical for brain health, for the first time in their natural state. Astrocytes are ...

Zhang et al. used a conditional knockout mouse model to re-examine the role of the RNA-binding protein PTBP1 in the transdifferentiation of astroglial cells into neurons. Several earlier studies ...

The link between Alzheimer’s disease and amyloid plaques is well documented, with innumerable studies exploring techniques and therapies to inhibit plaque formation, preventing development or ...