The Detroit Lions will play one of four teams in their playoff opener next week: The Rams, Packers, Vikings or Commanders.

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The reigning two-time Super Bowl champions closed out the regular season with a 38-0 blowout loss to the Denver Broncos on Sunday after electing to sit most of their starters. Still, the Chiefs' 15-2 record was tied with the Detroit Lions for the best in the NFL, despite winning 10 of their games by seven points or fewer.

The regular season is done and through a series of close wins, combined with a strong finish before Week 18, the Chiefs went 15-2. They're the No. 1 seed in the AFC and they're two home wins from another Super Bowl. A couple teams from our list of the five biggest threats to knock off the Chiefs didn't even make the playoffs. A few remain.

Home games against the Dallas Cowboys, Pittsburg Steelers and Tampa Bay Buccaneers highlight the Lions' 2025 schedule. In addition to hosting NFC North rivals Green Bay Packers, Chicago Bears and Minnesota Vikings, the Lions will welcome in the Cowboys, Buccaneers (NFC South champions), Steelers, New York Giants and Cleveland Browns.

The Detroit Lions are the favorites to win Super Bowl 2025 entering NFL playoffs after a huge win over the Minnesota Vikings in Week 18.

Since the Lions won the NFC North after beating the Minnesota Vikings in Week 18, that means they will face the division winners from the AFC West (Kansas City Chiefs), NFC South (Tampa Bay Buccaneers) and NFC West (Los Angeles Rams).

Jahmyr Gibbs delivered spinning stiff-arms and bolted through webs of would-be tacklers for a 170-yard, four-touchdown performance, leading the Detroit Lions over the Minnesota Vikings in their regular-season finale.

The Lions running back had 139 yards and three touchdowns on the ground to go along with 31 yards receiving and another score in the air.

The Lions still have work to do this season, but their 2025 opponents — which include nine teams that made the 2024 playoffs —have been set.