Background The mixed connective tissue disease (MCTD) is an autoimmune systemic disease characterised by clinical manifestations that are included in systemic lupus erythematous (SLE), scleroderma ...

3 Department of Rheumatology, University of Edinburgh, Centre for Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK 4 Department of Medicine, Rheumatology Section, Alicante ...

Background Calcium/Calmodulin-dependent protein kinase IV (CaMK4) is a serine kinase expressed in CD4 T cells whom activity is increased in patients with active systemic lupus erythematosus (SLE). We ...

Free radicals and inflammation. P G Winyard, D R Blake, C H Evans. (Pp 272; DM238.) Basle: Birkhauser Verlag AG, 2000. ISBN 3-7643-5851-3. Understanding the genesis, propagation, and persistence of ...

Objective In 2011, the American College of Rheumatology (ACR) and EULAR endorsed provisional criteria for remission in rheumatoid arthritis (RA), both Boolean-based and index-based. Based on recent ...

Objectives In this study, we employ a multiomic approach to identify major cell types and subsets, and their transcriptomic profiles within the infrapatellar fat pad (IFP), and to determine ...

4 Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China 5 National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, ...

Objective Whether HMG-CoA-reductase inhibition, the main mechanism of statins, plays a role in the pathogenesis of osteoporosis, is not entirely known so far. Consequently, this study was set out to ...

Background Gout patients are more clinically complex than 20 years ago due to advanced age, comorbidities and polypragmasia. A lot of patients have contraindications or refractoriness to ...

Background Even it is accepted among rheumatologists that rheumatoid arthritis (RA) does not involve the facet joints (FJs) of the spine, the issue is still under debate. Studies that described a ...

Objectives Fibromyalgia is commonly considered a stress-related chronic pain disorder, and daily stressors are known triggers. However, the relation between stress and pain development remains poorly ...

1 Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA 2 Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, UT, USA ...