A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure ...

When a vertebrate embryo develops, a group of cells self-organizes into the neural tube, eventually becoming the brain and the spinal cord. This involves specific signals, but how these signals are ...

In about one out of every 1,000 pregnancies, the neural tube, a key nervous system structure, fails to close properly. Georgia Tech physicists are now helping explain why this happens, having ...

Discover the first images of cytonemes during mammalian neural development, serving as express routes to establish morphogen gradients and tissue patterning. St. Jude Children's Research Hospital ...

Precursor cells in the embryonic neural tube are organized in a specific striped pattern which depends on the signals they receive (left). Lehr and colleagues recreated this pattern in a cell culture ...

Bioengineering researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a soft, thin, stretchable bioelectronic device that can be implanted into a ...

Quails are small, plump birds that scurry through grasslands on foot rather than take to the skies. Unexpectedly, studying these ground-dwellers has helped scientists uncover clues about a type of ...