Upon starting methotrexate treatment, LDH and albumin levels may be signals for AKIs in patients with hematologic malignancies. Among patients with hematologic malignancies treated with methotrexate, ...

Disease-modifying drug therapies are being sought intensively for osteoarthritis (OA), but none have proved out thus far. A previous trial in patients with OA of the hand had found that methotrexate ...

July 22, 2009 — Intensive treatment with methotrexate may be helpful in early rheumatoid arthritis despite greater adverse events vs conventional treatment, according to the results of a study ...

Methotrexate significantly lowers systolic blood pressure in newly diagnosed RA patients compared to sulfasalazine, potentially reducing cardiovascular risk. The study provides prospective comparative ...

Adalimumab monotherapy and combination with methotrexate showed similar drug survival and PASI75 response rates in plaque psoriasis patients. Methotrexate reduced antidrug antibody levels but did not ...

Twenty doses of outpatient HD-MTX with glucarpidase were administered to seven patients. After 20 of 20 (100%) treatments, serum MTX levels were reduced to <100 nmol/L. Treatments were well-tolerated, ...

Researchers develop targeted polymersomes to enhance methotrexate delivery, offering a promising new approach for treating aggressive choriocarcinoma. Study: ENT-1-Targeted Polymersomes to Enhance the ...

Subcutaneous tocilizumab, either as monotherapy or in combination with methotrexate, demonstrated greater efficacy than methotrexate alone and was well tolerated in patients with active rheumatoid ...

In July 2022, the US Food and Drug Administration (FDA) expanded the labeling of Krystexxa (pegloticase; Horizon Therapeutics), a PEGylated uric acid-specific enzyme, to include coadministration with ...

This approval provides patients with a new generic option for the folate analog metabolic inhibitor, which is used to treat ...