Schematic diagram depicting the mechanism of the rigid matrix regulating cell glycolysis in degenerated NPCs. In degenerated NP tissue, MRTF-A was activated by increased matrix stiffness and ...

Organ failure impacts millions of patients each year and costs hundreds of billions of US Dollars. Over the last 30 years, scientists have utilized a combination of tools, methods, and molecules of ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 36 (September 7, 2021), pp. 1-8 (8 pages) Mechanical forces generated by cells and the tension of the ...

(Nanowerk News) Imagine a world inside your body where tiny cells are like workers building and repairing tissue structures. They interact with their surroundings, which include a scaffold called the ...

MTF Biologics, a global nonprofit organization that saves and heals lives by advancing tissue and organ donation, ...

Tissue engineering is an interdisciplinary field that combines principles from engineering, biology, and materials science to develop biological substitutes that restore, maintain, or improve tissue ...

These fields aim to facilitate healing and restore lost function in damaged or diseased tissues and organs by integrating scaffolds, cells, and biological signaling molecules. This combination aims to ...

For in vitro cellular assays, the extracellular matrix—the material between cells—often is overlooked, but changes within this microenvironment affect cells’ proliferation and differentiation and, ...

Bone implants often fail to fully integrate with surrounding tissue, limiting their effectiveness in regeneration. A natural but often overlooked cellular process could hold the key to better outcomes ...

Materials like zirconia and alumina offer high strength, low friction, and wear resistance, making them suitable for load-bearing applications such as joint replacements and dental implants. Other ...