Nature

Factor B structure provides insights into activation of the central protease of the complement system

Figure 1: C3 convertase formation and crystal structure of complement factor B. Figure 2: Regulatory elements in the VWA domain.
News Medical

The complement cascade and its therapeutic potential in COVID-19, cancer and general inflammation

Global understanding of complement has shifted and developed since the 21st century: from our idea of a blood-based antibiotic system to a global regulator of immunity and tissue homeostasis. Recent ...
Business Wire

Gemini Therapeutics Announces FDA Fast Track Designation Granted for GEM103 for the Treatment of Dry Age-Related Macular Degeneration (AMD) in Patients With Complement Factor H ...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Gemini Therapeutics, a clinical stage precision medicine company developing innovative treatments for genetically defined age-related macular degeneration (AMD), ...
News Medical

Role of complement factor H-related protein 5 in venous thromboembolism and COVID-19

A recent article posted to the medRxiv* preprint server discussed the role of complement factor H-related protein 5 (CFHR5) in venous thromboembolism (VTE) patients and hospitalized coronavirus ...